RATED R 2004 In 1952, twenty-three year old medical student, one semester away from graduation, decides to postpone his last semester to accompany his twenty-nine year old biochemist friend on his four month, 8,000 km-long dream motorcycle trip throughout South America starting from their home in Buenos Aires. Their quest is to see things they've only read about in books about the continent on which they live, and to finish that quest on Alberto's thirtieth birthday on the other side of the continent in the Guajira Peninsula in Venezuela. Not all on this trip goes according to their rough plan due to a broken down motorbike, a continual lack of money, arguments between the two in their isolation with each other, their raging libidos which sometimes get them into trouble, and dealing with Fuser's chronic asthma. But a chance encounter with a couple of Communists in the Chilean desert and an extended visit to the San Pablo Leper Colony in the Perúvian Amazon Basin among other things profoundly affects what each will want to do with his life and the bond each has with the other.